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Submit ReviewSipatrigine
Description: NaV blocker; neuroprotective
Alternative Names: 619C89
Chemical Name: 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
Purity: ≥99% (HPLC)
Biological Activity for Sipatrigine
Sipatrigine is a blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611).
Technical Data for Sipatrigine
| M. Wt | 372.68 |
| Formula | C15H16Cl3N5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 130800-90-7 |
| PubChem ID | 60803 |
| InChI Key | PDOCBJADCWMDGL-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sipatrigine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.27 | 100 | |
| ethanol | 9.32 | 25 |
Preparing Stock Solutions for Sipatrigine
The following data is based on the product molecular weight 372.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.42 mL | 26.83 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for Sipatrigine
References for Sipatrigine
References are publications that support the biological activity of the product.
Leach et al (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24 1063 PMID: 8100654
Graham et al (1994) Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 269 854 PMID: 7910213
Stefani et al (1998) On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 125 1058 PMID: 9846645
If you know of a relevant reference for Sipatrigine, please let us know.
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Keywords: Sipatrigine, Sipatrigine supplier, nav, voltage-dependent, sodium, Na+, channels, blockers, neuroprotective, 619C89, Voltage-gated, Sodium, Channels, 4044, Tocris Bioscience
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