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SJF 0661

Cat. No. 7464 Submit a Review Datasheet / COA / SDS
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Description: Negative control for SJF 0628 (Cat. No. 7463)
Chemical Name: (2S,4S)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SJF 0661

SJF 0661 is the negative control for SJF 0628 (Cat. No. 7463). Binds BRAF without inducing degradation.

Technical Data for SJF 0661

M. Wt 1010.19
Formula C51H57F2N9O7S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2413035-43-3
PubChem ID 146502225
InChI Key MBCAVOCJJAQHHT-NYNRYUPBSA-N
Smiles CCCS(=O)(NC1=CC=C(C(C(C2=CNC3=NC=C(C4=CC=C(N5CCN(CC5)CC(N[C@@H](C(C)(C)C)C(N6C[C@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O)C=C4)C=C23)=O)=C1F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJF 0661

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 101.02 100

Preparing Stock Solutions for SJF 0661

The following data is based on the product molecular weight 1010.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.95 mL 9.9 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.49 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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References for SJF 0661

References are publications that support the biological activity of the product.

Alabi et al (2021) Mutant-selective degradation by BRAF-targeting PROTACs. Nat.Commun. 12 PMID: 33568647

If you know of a relevant reference for SJF 0661, please let us know.

View Related Products by Target

Keywords: SJF 0661, SJF 0661 supplier, SJF0661, negative, control, degraders, degradation, PROTAC, raf, BRAFV600E, kinase, Raf, Kinase, Negative, Controls, 7464, Tocris Bioscience

Citations for SJF 0661

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
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  • Degrader Building Blocks
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia