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Submit ReviewSKF 86002 dihydrochloride
Description: p38 MAPK inhibitor; anti-inflammatory agent
Chemical Name: 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SKF 86002 dihydrochloride
Inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.
Technical Data for SKF 86002 dihydrochloride
| M. Wt | 370.27 |
| Formula | C16H12FN3S.2HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 116339-68-5 |
| PubChem ID | 10339107 |
| InChI Key | GQQCNUNCYVXBTF-UHFFFAOYSA-N |
| Smiles | Cl.Cl.FC1=CC=C(C=C1)C1=C(N2CCSC2=N1)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SKF 86002 dihydrochloride
References for SKF 86002 dihydrochloride
References are publications that support the biological activity of the product.
Griswold et al (1987) SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 36 3463 PMID: 2823821
Lee et al (1994) A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 372 739 PMID: 7997261
Nick et al (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 99 975 PMID: 9062356
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Keywords: SKF 86002 dihydrochloride, SKF 86002 dihydrochloride supplier, p38, MAP, kinases, inhibitors, inhibits, anti-inflammatory, agent, human, monocyte, IL-1, TNF-α, TNF-alpha, production, Mitogen-Activated, Protein, Kinase, MAPK, Signaling, Signalling, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, SKF86002, dihydrochl, 2008, Tocris Bioscience
1 Citation for SKF 86002 dihydrochloride
Citations are publications that use Tocris products. Selected citations for SKF 86002 dihydrochloride include:
Haas et al (2013) The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog 9 e1003737 PMID: 24244164
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SKF 86002 dihydrochloride
