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Submit ReviewSKF 91488 dihydrochloride
Description: Histamine N-methyltransferase inhibitor
Chemical Name: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
Biological Activity for SKF 91488 dihydrochloride
SKF 91488 dihydrochloride is a homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.
Technical Data for SKF 91488 dihydrochloride
| M. Wt | 248.21 |
| Formula | C7H17N3S.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 68941-21-9 |
| PubChem ID | 11957708 |
| InChI Key | NPLHSMBWWIIWAQ-UHFFFAOYSA-N |
| Smiles | CN(CCCCSC(=N)N)C.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SKF 91488 dihydrochloride
Certificate of Analysis is currently unavailable on-line.
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References for SKF 91488 dihydrochloride
References are publications that support the biological activity of the product.
Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354 PMID: 9089666
Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183 PMID: 34400
Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455 PMID: 161853
Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268 PMID: 1534842
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Citations for SKF 91488 dihydrochloride
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