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Submit ReviewSM 324405
Description: Potent TLR7 agonist
Chemical Name: Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
Purity: ≥98% (HPLC)
Biological Activity for SM 324405
SM 324405 is a potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma).
Compound Libraries for SM 324405
SM 324405 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for SM 324405
| M. Wt | 385.42 |
| Formula | C19H23N5O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 677773-91-0 |
| PubChem ID | 23079483 |
| InChI Key | MXILFZWMVNDOIZ-UHFFFAOYSA-N |
| Smiles | NC1=NC(OCCCC)=NC(N2CC3=CC=CC(CC(OC)=O)=C3)=C1NC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SM 324405
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.54 | 100 |
Preparing Stock Solutions for SM 324405
The following data is based on the product molecular weight 385.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.97 mL | 25.95 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.19 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for SM 324405
References for SM 324405
References are publications that support the biological activity of the product.
Kurimoto et al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964 PMID: 20232824
Biffen et al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573 PMID: 22122192
If you know of a relevant reference for SM 324405, please let us know.
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Keywords: SM 324405, SM 324405 supplier, SM324405, toll-like, receptors, TLR7, potent, agonists, agonism, Toll-like, Receptors, 5445, Tocris Bioscience
Citations for SM 324405
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