Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSMANT hydrochloride
Description: Inhibits Smoothened (Smo) accumulation
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SMANT hydrochloride
SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
Technical Data for SMANT hydrochloride
| M. Wt | 375.73 |
| Formula | C16H23BrN2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1177600-74-6 |
| PubChem ID | 2900213 |
| InChI Key | XQESCHFXROUCOQ-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SMANT hydrochloride
References for SMANT hydrochloride
References are publications that support the biological activity of the product.
Wang et al (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 7 1040 PMID: 22554036
View Related Products by Target
Keywords: SMANT hydrochloride, SMANT hydrochloride supplier, Smoothened, Smo, hedgehog, Hh, signaling, signalling, inhibitors, inhibits, SMANT, Receptors, Hedgehog, Signaling, 4662, Tocris Bioscience
Citations for SMANT hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for SMANT hydrochloride.
Reviews for SMANT hydrochloride
There are currently no reviews for this product. Be the first to review SMANT hydrochloride and earn rewards!
Have you used SMANT hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products