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Submit ReviewSN 003
Description: Potent and selective CRF1 antagonist
Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine
Purity: ≥98% (HPLC)
Biological Activity for SN 003
Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.
Technical Data for SN 003
| M. Wt | 355.43 |
| Formula | C19H25N5O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 197801-88-0 |
| PubChem ID | 10291750 |
| InChI Key | FZMBHAQCHCEGNN-UHFFFAOYSA-N |
| Smiles | CCC(COC)N2C1=CC(C)=NC(NC3=CC=C(OC)C=C3C)=C1N=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SN 003
References for SN 003
References are publications that support the biological activity of the product.
Kumar et al (2006) Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg.Med.Chem. 14 4029 PMID: 16529935
Sullivan et al (2007) PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density? Nucl.Med.Biol 34 353 PMID: 17499724
Zhang et al (2003) Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for cortic J.Pharm.Exp.Ther. 305 57
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Keywords: SN 003, SN 003 supplier, reversible, corticotropin, releasing, factor, receptors, 1, CRF1, CRF, antagonists, SN003, Receptors, 3294, Tocris Bioscience
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.