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Submit ReviewSpexin
Description: Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo
Alternative Names: NPQ,Neuropeptide Q
Purity: ≥95% (HPLC)
Biological Activity for Spexin
Spexin is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.
Technical Data for Spexin
| M. Wt | 1619.9 |
| Formula | C74H114N20O19S |
| Sequence |
NWTPQAMLYLKGAQ (Modifications: Gln-14 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1370290-58-6 |
| PubChem ID | 122705996 |
| InChI Key | ZZDZBDJTNIOJMF-TWMPYRTRSA-N |
| Smiles | [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Spexin
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Spexin
References for Spexin
References are publications that support the biological activity of the product.
Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 22 1643 PMID: 24550067
Reyes-Alcaraz et al (2016) Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 6 21453 PMID: 26907960
Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155 1864 PMID: 24517231
If you know of a relevant reference for Spexin, please let us know.
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Keywords: Spexin, Spexin supplier, Potent, galanin, receptors, 2, 3, agonists, agonism, GAL, endogenous, satiety, inducing, peptides, anxiolytic, anxiety, diabetes, obesity, NPQ, Neuropeptide, Q, Galanin, Receptors, 6090, Tocris Bioscience
Citations for Spexin
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.