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Submit ReviewSplitomicin
Description: Sir2p inhibitor
Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Purity: ≥97% (HPLC)
Biological Activity for Splitomicin
Splitomicin is a inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
Technical Data for Splitomicin
| M. Wt | 198.22 |
| Formula | C13H10O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 5690-03-9 |
| PubChem ID | 5269 |
| InChI Key | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| Smiles | O=C1CCC2=C(O1)C=CC1=CC=CC=C21 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Splitomicin
References for Splitomicin
References are publications that support the biological activity of the product.
Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113 PMID: 11752457
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Keywords: Splitomicin, Splitomicin supplier, Sir2p, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Class, III, HDACs, (Sirtuins), 1542, Tocris Bioscience
2 Citations for Splitomicin
Citations are publications that use Tocris products. Selected citations for Splitomicin include:
Kumari and Usdin (2014) Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription. Hum Mol Genet 23 6575 PMID: 25055869
Stavrou et al (2015) Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. J Neurosci 125 710 PMID: 25339356
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