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Submit ReviewSR 3576
Description: Highly potent and selective JNK3 inhibitor
Chemical Name: 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
Purity: ≥97% (HPLC)
Biological Activity for SR 3576
SR 3576 is a highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38.
Compound Libraries for SR 3576
SR 3576 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for SR 3576
| M. Wt | 501.53 |
| Formula | C27H27N5O5 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1164153-22-3 |
| PubChem ID | 70702008 |
| InChI Key | MTFAYLZZDJGFGV-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC(OC)=C(OC)C(OC)=C3)C1=CC=CC(N2C=C(NC(NC4=CC=CC(C)=C4)=O)C=N2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 3576
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.15 | 100 |
Preparing Stock Solutions for SR 3576
The following data is based on the product molecular weight 501.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for SR 3576
References for SR 3576
References are publications that support the biological activity of the product.
Kamenecka et al (2009) Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 284 12853 PMID: 19261605
If you know of a relevant reference for SR 3576, please let us know.
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Keywords: SR 3576, SR 3576 supplier, SR3576, c-Jun, N-terminal, kinase, 3alpha1, JNK3alpha1, highly, potent, selective, inhibitors, inhibits, JNK/c-jun, 5044, Tocris Bioscience
Citations for SR 3576
Citations are publications that use Tocris products.
Currently there are no citations for SR 3576. Do you know of a great paper that uses SR 3576 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SR 3576
