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Submit ReviewSSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.
SSR 149415 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 630.11 |
Formula | C30H32ClN3O8S |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 439687-69-1 |
PubChem ID | 9895468 |
InChI Key | NJXZWIIMWNEOGJ-WEWKHQNJSA-N |
Smiles | COC1=CC(OC)=C(S(=O)(N2C([C@@](C3=CC(Cl)=CC=C23)(C4=C(C=CC=C4)OC)N5C[C@@H](C[C@H]5C(N(C)C)=O)O)=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 63.01 | 100 | |
ethanol | 63.01 | 100 |
The following data is based on the product molecular weight 630.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.59 mL | 7.94 mL | 15.87 mL |
5 mM | 0.32 mL | 1.59 mL | 3.17 mL |
10 mM | 0.16 mL | 0.79 mL | 1.59 mL |
50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
References are publications that support the biological activity of the product.
Serradeil-Le Gal et al (2005) An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 11 53 PMID: 15867952
If you know of a relevant reference for SSR 149415, please let us know.
Keywords: SSR 149415, SSR 149415 supplier, SSR149415, vasopressin, receptor, V1b, potent, selective, antagonists, antagonism, orally, bioavailable, Nelivaptan, Vasopressin, Receptors, 6195, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SSR 149415 include:
Pung-Pung et al (2020) Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes. Int J Mol Sci 21 PMID: 32486459
Mengliang et al (2021) Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury. Elife 10 PMID: 34372969
Do you know of a great paper that uses SSR 149415 from Tocris? Please let us know.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.