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Submit ReviewST 045849
Description: O-GlcNAc transferase (OGT) inhibitor
Chemical Name: 2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for ST 045849
ST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.
Technical Data for ST 045849
| M. Wt | 446.99 |
| Formula | C23H27ClN2O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 442665-87-4 |
| PubChem ID | 4297469 |
| InChI Key | HLPZEZRNGAXCJH-UHFFFAOYSA-N |
| Smiles | OC(C1CC(N(/C(S1)=N/C2=CC=C(C=C2)Cl)CCC34CC5CC(C4)CC(C3)C5)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ST 045849
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.7 | 100 | |
| ethanol | 44.7 | 100 |
Preparing Stock Solutions for ST 045849
The following data is based on the product molecular weight 446.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.19 mL | 22.37 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.47 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets for ST 045849
References for ST 045849
References are publications that support the biological activity of the product.
Itkonen et al (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 7 12464 PMID: 26824323
Kim et al (2017) Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci.Rep. 7 11107 PMID: 28894244
Kim et al (2014) Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug.Chem. 25 1025 PMID: 24866374
If you know of a relevant reference for ST 045849, please let us know.
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Keywords: ST 045849, ST 045849 supplier, ST045849, O-GlcNAc, O-linked, N-acetylglucosamine, transferase, OGT, inhibitors, inhibits, glycosylation, glycolysis, O-GlcNAcylation, hyperglycemia, Other, Transferases, 6775, Tocris Bioscience
1 Citation for ST 045849
Citations are publications that use Tocris products. Selected citations for ST 045849 include:
Edoardo et al (2022) O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis. Nat Commun 13 5212 PMID: 36064721
Do you know of a great paper that uses ST 045849 from Tocris? Please let us know.
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