Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSTF 118804
Description: NAMPT inhibitor; depletes leukemia stem cells
Chemical Name: 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for STF 118804
STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.
Technical Data for STF 118804
| M. Wt | 461.53 |
| Formula | C25H23N3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 894187-61-2 |
| PubChem ID | 20916937 |
| InChI Key | DLFCEZOMHBPDGI-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for STF 118804
References for STF 118804
References are publications that support the biological activity of the product.
Matheny et al (2013) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem.Biol. 20 1352 PMID: 24183972
View Related Products by Target
View Related Products by Product Action
Keywords: STF 118804, STF 118804 supplier, STF118804, NAMPT, inhibitors, inhibits, potent, nicotinamide, phosphoribosyltransferase, visfatin, PBEF1, cytotoxic, Cancer, Stem, Cells, 5207, Tocris Bioscience
1 Citation for STF 118804
Citations are publications that use Tocris products. Selected citations for STF 118804 include:
Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867
Reviews for STF 118804
Average Rating: 5 (Based on 1 Review.)
Have you used STF 118804?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
It works well for cell culture..
By
Anonymous on 05/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: human astrocytes
After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.