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Submit ReviewSU 11274
Description: Selective inhibitor of MET kinase activity
Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
Purity: ≥97% (HPLC)
Biological Activity for SU 11274
Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.
Technical Data for SU 11274
| M. Wt | 568.09 |
| Formula | C28H30ClN5O4S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 658084-23-2 |
| PubChem ID | 9549297 |
| InChI Key | FPYJSJDOHRDAMT-KQWNVCNZSA-N |
| Smiles | CC1=C(\C=C(C3=CC(S(N(C)C5=CC(Cl)=CC=C5)(=O)=O)=CC=C3N4)/C4=O)NC(C)=C1C(N2CCN(C)CC2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SU 11274
References for SU 11274
References are publications that support the biological activity of the product.
Sattler et al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462 PMID: 14500382
Wang et al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085 PMID: 14617781
Seiwert et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021 PMID: 19318576
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Keywords: SU 11274, SU 11274 supplier, SU11274, Supplier, c-Met, inhibitors, inhibits, MET, tyrosine, kinase, activity, met, receptors, Receptors, 4101, Tocris Bioscience
5 Citations for SU 11274
Citations are publications that use Tocris products. Selected citations for SU 11274 include:
Jiang et al (2015) YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. Blood 13 280 PMID: 26310485
Sullivan et al (2012) ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Springerplus 8 646 PMID: 22660439
Shibasaki et al (2014) Differential regulation of c-Met signaling pathways for synovial cell function. J Transl Med 3 554 PMID: 25332857
Dai et al (2012) Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem 287 14586 PMID: 22418436
Boyd et al (2013) Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments. Tissue Eng Part A 19 211 PMID: 22971005
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