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Description: Basic fibroblast growth factor (bFGF) mimetic; neuroprotective
Chemical Name: 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for SUN 11602
SUN 11602 is a basic fibroblast growth factor (bFGF) mimetic. Mimics the neuroprotective effects of bFGF; prevents glutamate-induced neuronal death. Increases levels of CALB1 gene expression in cerebrocortical neurons. Triggers phosphorylation of FGFR, ERK1 and ERK2.
Technical Data for SUN 11602
| M. Wt | 451.61 |
| Formula | C26H37N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 704869-38-5 |
| PubChem ID | 22245705 |
| InChI Key | KCODNOOPOPTZMO-UHFFFAOYSA-N |
| Smiles | NC1=C(C)C(C)=C(NCC(N(C)C2CCN(CC3=CC=C(C(N)=O)C=C3)CC2)=O)C(C)=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SUN 11602
References for SUN 11602
References are publications that support the biological activity of the product.
Murayama et al (2013) SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. ACS Chem.Neurosci. 4 266 PMID: 23421678
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Keywords: SUN 11602, SUN 11602 supplier, SUN11602, basic, fibroblast, growth, factor, bFGF, calcium, binding, protein, calbindin-D28k, Calb, FGFR, receptor, ERK1, ERK2, 4826, Tocris Bioscience
Citations for SUN 11602
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