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Submit ReviewSUN-B 8155
Description: Non-peptide calcitonin agonist
Chemical Name: 5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridone
Biological Activity for SUN-B 8155
SUN-B 8155 is a non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50 = 21 μM). Causes a significant reduction in serum calcium concentrations in vivo following i.p. administration.
Compound Libraries for SUN-B 8155
SUN-B 8155 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SUN-B 8155
| M. Wt | 273.29 |
| Formula | C14H15N3O3 |
| Storage | Store at +4°C |
| CAS Number | 345893-91-6 |
| PubChem ID | 16079007 |
| InChI Key | IMUCOECFKIWBSW-LCYFTJDESA-N |
| Smiles | O=C1C=C(C)C(/C(C)=N/C2=C(N)C=CC=C2)=C(O)N1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SUN-B 8155
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.32 | 100 |
Preparing Stock Solutions for SUN-B 8155
The following data is based on the product molecular weight 273.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.66 mL | 18.3 mL | 36.59 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
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Product Datasheets for SUN-B 8155
References for SUN-B 8155
References are publications that support the biological activity of the product.
Katayama et al (2001) Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin. Biochim.Biophys.Acta 1526 183 PMID: 11325540
If you know of a relevant reference for SUN-B 8155, please let us know.
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Keywords: SUN-B 8155, SUN-B 8155 supplier, Non-peptide, calcitonin, CT, receptors, agonists, SUNB8155, Calcitonin, and, Related, Receptors, 2550, Tocris Bioscience
Citations for SUN-B 8155
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.