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Submit ReviewSuplatast tosylate
Description: Th2 cytokine synthesis inhibitor; antiasthmatic
Alternative Names: IPD 1151T
Chemical Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium 4-methylbenzenesulfonate
Purity: ≥99% (HPLC)
Biological Activity for Suplatast tosylate
Suplatast tosylate is a th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
Technical Data for Suplatast tosylate
| M. Wt | 499.64 |
| Formula | C16H26NO4S.C7H7O3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 94055-76-2 |
| PubChem ID | 71773 |
| InChI Key | RYVJQEZJUFRANT-UHFFFAOYSA-N |
| Smiles | O=C(CC[S+](C)C)NC1=CC=C(OCC(O)COCC)C=C1.CC2=CC=C(S(=O)([O-])=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Suplatast tosylate
References for Suplatast tosylate
References are publications that support the biological activity of the product.
Kurokawa et al (2001) Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo. Mediators Inflamm. 10 333 PMID: 11817674
Hsu et al (2007) The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells. Transpl.Immunol. 18 108 PMID: 18005853
Furonaka et al (2009) Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice. J.Pharmacol.Exp.Ther. 328 55 PMID: 18832650
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Keywords: Suplatast tosylate, Suplatast tosylate supplier, Th2, cytokine, synthesis, inhibitors, inhibits, antiasthmatic, TNF-α, TNF-alpha, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, IPD1151T, IPD, 1151T, 3543, Tocris Bioscience
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