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Surfen

Cat. No. 6634 Submit a Review Datasheet / COA / SDS
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Description: Heparin sulfate antagonist
Chemical Name: N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Surfen

Surfen is a heparan sulfate antagonist. Inhibits heparan sulfate-mediated cell attachment in vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.

Compound Libraries for Surfen

Surfen is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Surfen

M. Wt 445.35
Formula C21H20N6O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 5424-37-3
PubChem ID 79472
InChI Key GKQYGRWQCWWSHN-UHFFFAOYSA-N
Smiles CC1=NC2=CC=C(C=C2C(N)=C1)NC(NC3=CC=C4N=C(C=C(C4=C3)N)C)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Surfen

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.91 20
DMSO 8.91 20

Preparing Stock Solutions for Surfen

The following data is based on the product molecular weight 445.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.23 mL 56.14 mL 112.27 mL
1 mM 2.25 mL 11.23 mL 22.45 mL
2 mM 1.12 mL 5.61 mL 11.23 mL
10 mM 0.22 mL 1.12 mL 2.25 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Surfen

References are publications that support the biological activity of the product.

Schuksz et al (2008) Surfen, a small molecule antagonist of heparan sulfate. Proc.Natl.Acad.Sci.USA 105 13074 PMID: 18725627

Huang et al (2018) Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells. 36 45 PMID: 28984039

If you know of a relevant reference for Surfen, please let us know.

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Citations for Surfen

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