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T 5224

Cat. No. 7317 Submit a Review Datasheet / COA / SDS
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Description: Selective inhibitor of c-Fos/activator protein (AP)-1
Chemical Name: 5-[4-(Cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]benzenepropanoic acid
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for T 5224

T 5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It inhibits the DNA-binding and transactivation activities of AP-1, without affecting the activity of ATF2, C/EBPα, NF-κB/p65, MyoD, and Sp1 in vitro. In a mouse model, T 5224 prevents type II collagen-induced arthritis by reducing inflammatory cytokines (including interleukin 1β) and matrix-degrading MMPs.

Technical Data for T 5224

M. Wt 517.53
Formula C29H27NO8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 530141-72-1
PubChem ID 23626877
InChI Key DALCQQSLNPLQFZ-UHFFFAOYSA-N
Smiles O=C(O)CCC1=CC(=CC=C1OCC2=CC=C3C(=O)NOC3=C2)C(=O)C4=CC=C(OC5CCCC5)C=C4O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 5224

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.75 100

Preparing Stock Solutions for T 5224

The following data is based on the product molecular weight 517.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for T 5224

References are publications that support the biological activity of the product.

Tsuchida et al (2006) Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J.Med.Chem 49 80 PMID: 16392794

Aikawa et al (2008) Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat.Biotechnol 26 817 PMID: 18587386

If you know of a relevant reference for T 5224, please let us know.

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Citations for T 5224

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