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Submit ReviewTafluprost
Description: Very high affinity FP receptor agonist
Chemical Name: 1-Methylethyl (5-Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoate
Purity: ≥95% (HPLC)
Biological Activity for Tafluprost
Tafluprost is a very high affinity FP receptor agonist (Ki = 0.4 nM). Reduces intraocular pressure (IOP) in animal models of ocular hypertension and normal animals.
Technical Data for Tafluprost
| M. Wt | 452.53 |
| Formula | C25H34F2O5 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 209860-87-7 |
| PubChem ID | 9868491 |
| InChI Key | WSNODXPBBALQOF-VEJSHDCNSA-N |
| Smiles | O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/C(F)(F)COC2=CC=CC=C2)[C@H](O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tafluprost
References for Tafluprost
References are publications that support the biological activity of the product.
Takagi et al (2004) Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp.Eye Res. 78 767 PMID: 15037111
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Keywords: Tafluprost, Tafluprost supplier, AFP-168, AFP168, ocular, hypertension, very, high, afifinity, FP, agonists, agonism, prostaglandins, IOP, Prostanoid, Receptors, 6427, Tocris Bioscience
Citations for Tafluprost
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Currently there are no citations for Tafluprost.
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