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Submit ReviewTAK 779
Description: Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Chemical Name: N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride
Purity: ≥98% (HPLC)
Biological Activity for TAK 779
TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.
Technical Data for TAK 779
| M. Wt | 531.13 |
| Formula | C33H39N2O2.Cl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 229005-80-5 |
| PubChem ID | 183789 |
| InChI Key | VDALIBWXVQVFGZ-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C2=CC(C=C(C(NC3=CC=C(C[N+](C)(C)C4CCOCC4)C=C3)=O)CCC5)=C5C=C2)C=C1.[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAK 779
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.31 | 10 | |
| DMSO | 2.66 | 5 |
Preparing Stock Solutions for TAK 779
The following data is based on the product molecular weight 531.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.83 mL | 94.14 mL | 188.28 mL |
| 0.5 mM | 3.77 mL | 18.83 mL | 37.66 mL |
| 1 mM | 1.88 mL | 9.41 mL | 18.83 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.77 mL |
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Product Datasheets for TAK 779
References for TAK 779
References are publications that support the biological activity of the product.
Baba et al (1999) A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc.Natl.Acad.Sci.U.S.A. 96 5698 PMID: 10318947
Suzaki et al (2008) A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur.Respir.J. 31 783 PMID: 18094012
Takami et al (2002) TAK-779, a nonpeptide CC chemokine receptor antagonist, protects the brain against focal cerebral ischemia in mice. J.Cereb.Blood Flow Metab. 22 780 PMID: 12142563
If you know of a relevant reference for TAK 779, please let us know.
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Keywords: TAK 779, TAK 779 supplier, TAK779, potent, selective, chemokines, receptors, antagonists, CCR5, CCR2, macrophage, viral, replication, ischemia, asthma, Chemokine, CC, Receptors, HIV, 4340, Tocris Bioscience
Citations for TAK 779
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