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Submit ReviewTalopram hydrochloride
Description: Potent, selective inhibitor of noradrenalin transporters
Alternative Names: Lu 3-010
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Talopram hydrochloride
Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).
Technical Data for Talopram hydrochloride
| M. Wt | 331.88 |
| Formula | C20H25NO.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 7013-41-4 |
| PubChem ID | 71176 |
| InChI Key | JZXJIRQPHHWYGC-UHFFFAOYSA-N |
| Smiles | CC2(C)OC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Talopram hydrochloride
References for Talopram hydrochloride
References are publications that support the biological activity of the product.
Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of DA, NE, and serotonin uptake. J.Med.Chem. 28 1817 PMID: 2999402
Eildal et al (2008) From the selective serotonin transporter inhibitor cital. to the selective NE transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045 PMID: 18429609
Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1
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