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Submit ReviewTAT-GluA2 3Y
Description: Inhibitor of AMPA receptor endocytosis
Biological Activity for TAT-GluA2 3Y
TAT-GluA2 3Y is an inhibitor of AMPA receptor endocytosis. Induces increased hind paw withdrawal latencies following thermal and mechanical stimuli in rats. Also exhibits antinociceptive effects in a rat model of neuropathic pain. Rescues pentobarbital-induced memory retrieval deficits in a rat model of learning and memory.
Technical Data for TAT-GluA2 3Y
| M. Wt | 2634 |
| Formula | C115H185N43O29 |
| Sequence | YGRKKRRQRRRYKEGYNVYG |
| Storage | Store at -20°C |
| CAS Number | 1404188-93-7 |
| InChI Key | JRFBJZYZNDUYJM-ZLIURJSSNA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TAT-GluA2 3Y
References for TAT-GluA2 3Y
References are publications that support the biological activity of the product.
Wang et al (2018) Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression. Behav.Brain Res. 339 66 PMID: 29162383
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Keywords: TAT-GluA2 3Y, TAT-GluA2 3Y supplier, TAT-GluA23Y, inhibits, AMPA, receptors, AMPAR, endocytosis, neuropathic, pain, learning, memory, Receptors, 6847, Tocris Bioscience
Citations for TAT-GluA2 3Y
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