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Submit ReviewTAT-PDHPS1
Description: YAP inhibitor
Purity: ≥95% (HPLC)
Biological Activity for TAT-PDHPS1
TAT-PDHPS1 is a YAP inhibitor (Yes-associated protein inhibitor). It comprises the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), which activates protein phosphatase 2A (PP2A). This activation leads to the phosphorylation of YAP and the suppression of YAP-targeted genes. TAT-PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro and ovarian tumor growth in a subcutaneous xenograft mouse model.
Technical Data for TAT-PDHPS1
| M. Wt | 3744.32 |
| Formula | C156H280N62O45 |
| Sequence | GRKKRRQRRRPPQQIATTTASAATAAAIGATPRAK |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | NNCYONQIMWXOHL-MRKNDOTPSA-N |
| Smiles | O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAT-PDHPS1
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for TAT-PDHPS1
References for TAT-PDHPS1
References are publications that support the biological activity of the product.
Pan et al (2022) Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling. Mol.Cancer Ther. 21 1160 PMID: 35545004
If you know of a relevant reference for TAT-PDHPS1, please let us know.
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Keywords: TAT-PDHPS1, TAT-PDHPS1 supplier, Peptide, deregulated, in, hypertrophic, scar-1, PDHPS1, PDHPS1-TAT, YAP, PTPA, PP2A, yap, inhibitor, yes, associated, protein, Hippo/Yap, signaling, 7832, Tocris Bioscience
Citations for TAT-PDHPS1
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for TAT-PDHPS1
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
Notch Signaling Pathway
The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.