Home / Product Type / PROTAC® Degraders & Targeted Protein Degradation / Protein Degraders / Negative Controls / TBK1 control PROTAC® 4

TBK1 control PROTAC® 4

Cat. No. 7260 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative control for TBK1 PROTAC® 3i (Cat. No. 7259)
Chemical Name: (2S,4S)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TBK1 control PROTAC® 4

TBK1 control PROTAC® 4 is a negative control for TBK1 PROTAC® 3i (Cat. No. 7259). Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for TBK1 control PROTAC® 4

M. Wt 1093.19
Formula C53H74BrN9O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2052306-31-5
PubChem ID 145969727
InChI Key QMGHHBHPDDAGGO-JTTRWUFTSA-N
Smiles CN(C(C1CCC1)=O)CCCNC2=NC(NC3=CC=C(C=C3)OCCCOCCCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](C[C@H]4C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)O)=O)=O)=NC=C2Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TBK1 control PROTAC® 4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 109.32 100

Preparing Stock Solutions for TBK1 control PROTAC® 4

The following data is based on the product molecular weight 1093.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.57 mL 9.15 mL
5 mM 0.18 mL 0.91 mL 1.83 mL
10 mM 0.09 mL 0.46 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for TBK1 control PROTAC® 4

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for TBK1 control PROTAC® 4

References are publications that support the biological activity of the product.

Crew et al (2018) Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1. J.Med.Chem. 61 583 PMID: 28692295

If you know of a relevant reference for TBK1 control PROTAC® 4, please let us know.

View Related Products by Target

Keywords: TBK1 control PROTAC® 4, TBK1 control PROTAC® 4 supplier, TANK-binding, kinase, 1, TBK1, potent, Degrader, Degraders, PROTACs, PROTAC, targeted, protein, degradation, TPD, von, Hippel, Lindau, VHL, E3, ligase, negative, control, TANK, binding, (TBK), Negative, Controls, 7260, Tocris Bioscience

Citations for TBK1 control PROTAC® 4

Citations are publications that use Tocris products.

Currently there are no citations for TBK1 control PROTAC® 4. Do you know of a great paper that uses TBK1 control PROTAC® 4 from Tocris? Please let us know.

Reviews for TBK1 control PROTAC® 4

There are currently no reviews for this product. Be the first to review TBK1 control PROTAC® 4 and earn rewards!

Have you used TBK1 control PROTAC® 4?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia