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Submit ReviewTC 1698 dihydrochloride
Discontinued Product
2518 has been discontinued.
Description: α7-selective agonist
Chemical Name: 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for TC 1698 dihydrochloride
TC 1698 dihydrochloride is a selective nicotinic α7 receptor agonist (EC50 = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.
Technical Data for TC 1698 dihydrochloride
| M. Wt | 275.22 |
| Formula | C13H18N2.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 787587-06-8 |
| PubChem ID | 21094258 |
| InChI Key | ZQUQBCHNSBJMCG-UHFFFAOYSA-N |
| Smiles | C1(C2N3CCC(CC3)CC2)=CC=CN=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC 1698 dihydrochloride
References for TC 1698 dihydrochloride
References are publications that support the biological activity of the product.
Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16 PMID: 14722323
Papke et al (2005) Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11 PMID: 16266703
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Keywords: TC 1698 dihydrochloride, TC 1698 dihydrochloride supplier, α7, alpha7-selective, agonists, α7Nicotinic, a7Nicotinic, Receptors, Acetylcholine, nAChR, TC1698, dihydrochloride, Nicotinic, (a7), 2518, Tocris Bioscience
Citations for TC 1698 dihydrochloride
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Currently there are no citations for TC 1698 dihydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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