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Submit ReviewTC-C 14G
Description: High affinity and potent CB1 inverse agonist
Chemical Name: [2-(2,4-Dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)-1,3-benzodioxol-5-yl]-4-morpholinyl-methanone
Purity: ≥98% (HPLC)
Biological Activity for TC-C 14G
TC-C 14G is a potent, high affinity CB1 receptor inverse agonist (EC50 = 11 nM in cAMP assay; Ki = 4 nM). Demonstrates high efficacy in a hypothermia assay (ID50 = 5 mg/kg) in vivo.
Technical Data for TC-C 14G
| M. Wt | 492.3 |
| Formula | C24H17Cl2F2NO4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 656804-72-7 |
| PubChem ID | 22475020 |
| InChI Key | VUCKSZWMRCSPME-UHFFFAOYSA-N |
| Smiles | FC1=CC2=C(OC(C3=C(Cl)C=C(Cl)C=C3)(C4=CC=C(F)C=C4)O2)C=C1C(N5CCOCC5)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-C 14G
References for TC-C 14G
References are publications that support the biological activity of the product.
Alig et al (2008) Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity. J.Med.Chem. 51 2115 PMID: 18335976
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Keywords: TC-C 14G, TC-C 14G supplier, TC-C14G, cannabinoid, CB1, receptor, inverse, agonists, potent, high, affinity, Receptors, 4345, Tocris Bioscience
Citations for TC-C 14G
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.