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Description: Potent tankyrase inhibitor
Chemical Name: 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole
Purity: ≥98% (HPLC)
Biological Activity for TC-E 5001
TC-E 5001 is a dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.
Technical Data for TC-E 5001
| M. Wt | 409.46 |
| Formula | C20H19N5O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 865565-29-3 |
| PubChem ID | 16013184 |
| InChI Key | LQZSHPITKSPDLC-UHFFFAOYSA-N |
| Smiles | CC1=NN=C(SCC3=NC(C4=CC=C(OC)C=C4)=NO3)N1C2=CC=C(OC)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-E 5001
References for TC-E 5001
References are publications that support the biological activity of the product.
Shultz et al (2012) [1,2,4]Triazole-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127 PMID: 22260203
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Keywords: TC-E 5001, TC-E 5001 supplier, TC-E5001, TNKS1, TNKS2, tankyrase, inhibitors, inhibits, wnt, signaling, signalling, Poly(ADP-ribose), Polymerase, Tankyrase, 5049, Tocris Bioscience
Citations for TC-E 5001
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