Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTC-E 5003
Discontinued Product
5099 has been discontinued.
View all Protein Arginine Methyltransferases products.
Description: Selective PRMT1 inhibitor
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Purity: ≥98% (HPLC)
Biological Activity for TC-E 5003
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
Technical Data for TC-E 5003
| M. Wt | 401.26 |
| Formula | C16H14Cl2N2O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 17328-16-4 |
| PubChem ID | 87052 |
| InChI Key | SHRCVZJKZJGIHQ-UHFFFAOYSA-N |
| Smiles | O=C(CCl)NC(C=C2)=CC=C2S(C1=CC=C(NC(CCl)=O)C=C1)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-E 5003
References for TC-E 5003
References are publications that support the biological activity of the product.
Bissinger et al (2011) Acyl derivatives of p-aminosulfonamides and dap. as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg.Med.Chem. 19 3717 PMID: 21440447
View Related Products by Target
View Related Products by Product Action
Keywords: TC-E 5003, TC-E 5003 supplier, TC-E5003, selective, PRMT1, inhibitors, inhibits, protein, methyltransferases, arginine, epigenetics, histone, transferases, Protein, Arginine, Methyltransferases, 5099, Tocris Bioscience
1 Citation for TC-E 5003
Citations are publications that use Tocris products. Selected citations for TC-E 5003 include:
Min-Jung et al (2020) TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes. FEBS Lett 594 2923-2930 PMID: 32767856
Reviews for TC-E 5003
There are currently no reviews for this product. Be the first to review TC-E 5003 and earn rewards!
Have you used TC-E 5003?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.