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TC-I 15

Cat. No. 4527 4 Citations Submit a Review Datasheet / COA / SDS
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Description: Potent α2β1 inhibitor; displays antithrombotic activity in vivo
Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC-I 15

TC-I 15 is a potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

Licensing Information

Sold under license from the University of Pennsylvania.

Technical Data for TC-I 15

M. Wt 520.62
Formula C23H28N4O6S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 916734-43-5
PubChem ID 90488948
InChI Key XKLHCUGVLCGKKX-RBUKOAKNSA-N
Smiles CC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-I 15

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.06 100

Preparing Stock Solutions for TC-I 15

The following data is based on the product molecular weight 520.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.6 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for TC-I 15

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for TC-I 15

References are publications that support the biological activity of the product.

Borza et al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027 PMID: 22440900

Miller et al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719 PMID: 19141632

If you know of a relevant reference for TC-I 15, please let us know.

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Keywords: TC-I 15, TC-I 15 supplier, TC-I15, integrins, receptors, a2b1, alpha2beta1, α2β1, inhibitors, inhibits, potent, selective, active, in, vivo, antithrombotics, collagen, Integrins, Cell, Adhesion, Molecules, 4527, Tocris Bioscience

4 Citations for TC-I 15

Citations are publications that use Tocris products. Selected citations for TC-I 15 include:

Li et al (2018) Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun 9 3600 PMID: 30190514

Hunter et al (2021) Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol.Appl.Pharmacol. 428 115669 PMID: 34363821

Baghdadi (2018) Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature 557 714 PMID: 29795344

Viola et al (2020) Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. Elife 9 PMID: 33026975

Do you know of a great paper that uses TC-I 15 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.