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TC-MCH 7c

Cat. No. 4365 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist
Chemical Name: 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC-MCH 7c

TC-MCH 7c is a potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.

Technical Data for TC-MCH 7c

M. Wt 408.47
Formula C24H25FN2O3
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 864756-35-4
PubChem ID 11654412
InChI Key ANCFKYJMXNMYNZ-UHFFFAOYSA-N
Smiles O=C1C=C(OCC3=CC=C(F)C=C3)C=CN1C2=CC=C(OCCN4CCCC4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-MCH 7c

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 40.85 100
DMSO 20.42 50

Preparing Stock Solutions for TC-MCH 7c

The following data is based on the product molecular weight 408.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for TC-MCH 7c

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for TC-MCH 7c

References are publications that support the biological activity of the product.

Haga et al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883 PMID: 21190859

Ito et al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77 PMID: 19836369

If you know of a relevant reference for TC-MCH 7c, please let us know.

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2 Citations for TC-MCH 7c

Citations are publications that use Tocris products. Selected citations for TC-MCH 7c include:

Hi-Joon et al (2019) Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice. Mol Neurobiol 56 2408-2423 PMID: 30030752

Hi-Joon et al (2020) Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents. Exp Neurobiol 29 453-469 PMID: 33372169

Do you know of a great paper that uses TC-MCH 7c from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.