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TC-N 1752

Cat. No. 4435 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: NaV channel blocker
Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC-N 1752

TC-N 1752 is a human NaV channel inhibitor (IC50 values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Compound Libraries for TC-N 1752

TC-N 1752 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-N 1752

M. Wt 516.52
Formula C25H27F3N6O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1211866-85-1
PubChem ID 53361524
InChI Key QLKAFHZJICDACE-UHFFFAOYSA-N
Smiles CC(C(NC(C)=O)=CC=C4)=C4NC1=NC=NC(N2CCC(OCC3=CC=C(OC(F)(F)F)C=C3)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-N 1752

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.65 100
1eq. HCl 5.17 10

Preparing Stock Solutions for TC-N 1752

The following data is based on the product molecular weight 516.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.36 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for TC-N 1752

References are publications that support the biological activity of the product.

Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427 PMID: 21634377

Lin et al (2016) Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells. PLoS One. 11 PMID: 27556810

If you know of a relevant reference for TC-N 1752, please let us know.

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Keywords: TC-N 1752, TC-N 1752 supplier, TCN1752, sodium, channels, blockers, selective, nav, analgesics, Voltage-gated, Sodium, Channels, 4435, Tocris Bioscience

2 Citations for TC-N 1752

Citations are publications that use Tocris products. Selected citations for TC-N 1752 include:

Douglas A et al (2021) TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. Cell Rep 34 108714 PMID: 33535052

Curtright et al (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One 10 e0116766 PMID: 25587718

Do you know of a great paper that uses TC-N 1752 from Tocris? Please let us know.

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