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Submit ReviewTCS JNK 5a
Description: Selective inhibitor of JNK2 and JNK3
Chemical Name: N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Purity: ≥99% (HPLC)
Biological Activity for TCS JNK 5a
TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).
Compound Libraries for TCS JNK 5a
TCS JNK 5a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for TCS JNK 5a
| M. Wt | 332.42 |
| Formula | C20H16N2OS |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 312917-14-9 |
| PubChem ID | 766949 |
| InChI Key | WQGDQGAFSDMBLA-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TCS JNK 5a
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.24 | 100 |
Preparing Stock Solutions for TCS JNK 5a
The following data is based on the product molecular weight 332.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for TCS JNK 5a
References for TCS JNK 5a
References are publications that support the biological activity of the product.
Angell et al (2007) N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 17 1296 PMID: 17194588
If you know of a relevant reference for TCS JNK 5a, please let us know.
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Keywords: TCS JNK 5a, TCS JNK 5a supplier, Selective, inhibitors, inhibits, JNK2, JNK3, Mitogen-Activated, Protein, Kinases, MAPK, c-Jun, N-Terminal, SAPKs, Stress-Activated, TCSJNK5a, JNK/c-jun, 2827, Tocris Bioscience
Citations for TCS JNK 5a
Citations are publications that use Tocris products.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for TCS JNK 5a
