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Submit ReviewTegaserod maleate
Description: 5-HT4 partial agonist
Chemical Name: 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
Purity: ≥99% (HPLC)
Biological Activity for Tegaserod maleate
Tegaserod maleate is a partial agonist of 5-HT4 (Ki = 12 nM).
Technical Data for Tegaserod maleate
| M. Wt | 417.46 |
| Formula | C16H23N5O.C4H4O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 189188-57-6 |
| PubChem ID | 135413539 |
| InChI Key | CPDDZSSEAVLMRY-FEQFWAPWSA-N |
| Smiles | O=C(/C=C\C(O)=O)O.CCCCCNC(N/N=C/C1=CNC2=C1C=C(OC)C=C2)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tegaserod maleate
References for Tegaserod maleate
References are publications that support the biological activity of the product.
Buchheit et al (1995) The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists. J.Med.Chem. 38 2331 PMID: 7608899
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Keywords: Tegaserod maleate, Tegaserod maleate supplier, Tegaserod, maleate, partial, 5-HT4, agonists, serotonergics, Receptors, 4613, Tocris Bioscience
1 Citation for Tegaserod maleate
Citations are publications that use Tocris products. Selected citations for Tegaserod maleate include:
Beattie et al (2011) The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol 2 25 PMID: 21687517
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.