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Terbinafine hydrochloride

Cat. No. 6484 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase
Chemical Name: N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Terbinafine hydrochloride

Terbinafine hydrochloride is a selective TASK3 activator (pEC50 = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

Technical Data for Terbinafine hydrochloride

M. Wt 327.89
Formula C21H25N.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 78628-80-5
PubChem ID 5282481
InChI Key BWMISRWJRUSYEX-SZKNIZGXSA-N
Smiles CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Terbinafine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.79 100
water 3.28 10 with gentle warming

Preparing Stock Solutions for Terbinafine hydrochloride

The following data is based on the product molecular weight 327.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.25 mL 30.5 mL
5 mM 0.61 mL 3.05 mL 6.1 mL
10 mM 0.3 mL 1.52 mL 3.05 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets for Terbinafine hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Terbinafine hydrochloride

References are publications that support the biological activity of the product.

Petranyi et al (1984) Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239 PMID: 6547247

Wright et al (2017) Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 493 444 PMID: 28882594

If you know of a relevant reference for Terbinafine hydrochloride, please let us know.

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1 Citation for Terbinafine hydrochloride

Citations are publications that use Tocris products. Selected citations for Terbinafine hydrochloride include:

Richard L et al (2021) Modulation of TASK-1/3 channels at the hypoglossal motoneuron pool and effects on tongue motor output and responses to excitatory inputs in vivo: implications for strategies for obstructive sleep apnea pharmacotherapy. Sleep 44 PMID: 32745213

Do you know of a great paper that uses Terbinafine hydrochloride from Tocris? Please let us know.

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