Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTicagrelor
Description: High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1
Chemical Name: (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
Purity: ≥98% (HPLC)
Biological Activity for Ticagrelor
Ticagrelor is a high affinity and reversible P2Y12 antagonist (pKi = 8.7) that displays inverse agonism in 1321N1 cells. Also high affinity inhibitor of equilibrative nucleoside transporter 1 (ENT1; Ki = 41 nM). Inhibits ADP-induced platelet aggregation.
Technical Data for Ticagrelor
| M. Wt | 522.57 |
| Formula | C23H28F2N6O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 274693-27-5 |
| PubChem ID | 9871419 |
| InChI Key | OEKWJQXRCDYSHL-FNOIDJSQSA-N |
| Smiles | CCCSC1=NC(N[C@@H]2C[C@H]2C2=CC(F)=C(F)C=C2)=C2N=NN([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)C2=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ticagrelor
References for Ticagrelor
References are publications that support the biological activity of the product.
Springthorpe et al (2007) From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. Bioorg.Med.Chem.Letts. 17 6013 PMID: 17827008
Aungraheeta et al (2016) Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 128 2717 PMID: 27694321
Armstrong et al (2014) Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1. J.Cardiovasc.Pharmacol.Ther. 19 209 PMID: 24414167
View Related Products by Target
View Related Products by Product Action
Keywords: Ticagrelor, Ticagrelor supplier, high, affinity, purinergic, P2Y12, receptor, antagonists, inverse, agonists, antagonism, agonism, ENT1, inhibitors, inhibits, equilibrative, nucleoside, transporter, antagonises, Purinergic, P2Y, Receptors, Nucleoside, Transporters, 6864, Tocris Bioscience
1 Citation for Ticagrelor
Citations are publications that use Tocris products. Selected citations for Ticagrelor include:
Li et al (2020) P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats. Biomed.Pharmacother. 132 110803 PMID: 33017768
Reviews for Ticagrelor
There are currently no reviews for this product. Be the first to review Ticagrelor and earn rewards!
Have you used Ticagrelor?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.