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Submit ReviewTipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.
M. Wt | 489.4 |
Formula | C27H22Cl2N4O |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 192185-72-1 |
PubChem ID | 159324 |
InChI Key | PLHJCIYEEKOWNM-HHHXNRCGSA-N |
Smiles | CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150
Keywords: Tipifarnib, Tipifarnib supplier, Potent, farnesyltransferase, inhibitors, inhibits, antitumor, cell, penetrant, orally, bioavailable, Protein, Prenyltransferases, Post-translational, Modifications, 6410, Tocris Bioscience
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