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TL 13-12

Cat. No. 6744 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective ALK Degrader (PROTAC®)
Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TL 13-12

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h.

Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for TL 13-12

M. Wt 961.48
Formula C45H53ClN10O10S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2229037-04-9
PubChem ID 138108740
InChI Key WXNUIPVZMJMPNM-UHFFFAOYSA-N
Smiles COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TL 13-12

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 96.15 100

Preparing Stock Solutions for TL 13-12

The following data is based on the product molecular weight 961.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.04 mL 5.2 mL 10.4 mL
5 mM 0.21 mL 1.04 mL 2.08 mL
10 mM 0.1 mL 0.52 mL 1.04 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

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References for TL 13-12

References are publications that support the biological activity of the product.

Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID: 29660984

If you know of a relevant reference for TL 13-12, please let us know.

View Related Products by Target

Keywords: TL 13-12, TL 13-12 supplier, TL13-12, protac, protacs, targeted, protein, degradation, TPD, active, degraders, degrades, ALK, Anaplastic, Lymphoma, Kinase, Degraders, 6744, Tocris Bioscience

1 Citation for TL 13-12

Citations are publications that use Tocris products. Selected citations for TL 13-12 include:

Ma et al (2023) Engineered PROTAC-CID systems for mammalian inducible gene regulation J Am Chem Soc 145 1593 PMID: 36626587

Do you know of a great paper that uses TL 13-12 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia