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Submit ReviewTLQP 21
Description: VGF-derived peptide
Purity: ≥95% (HPLC)
Biological Activity for TLQP 21
TLQP 21 is a VGF-derived peptide; spans residues 556-576 of the precursor sequence. Protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. Increases energy expenditure and prevents early phase diet-induced diabetes.
Technical Data for TLQP 21
| M. Wt | 2432.77 |
| Formula | C107H170N40O26 |
| Sequence | TLQPPASSRRRHFHHALPPAR |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 869988-94-3 |
| PubChem ID | 16158480 |
| InChI Key | PWWMOXVVMRPYJS-IWCKOKPFSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TLQP 21
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for TLQP 21
References for TLQP 21
References are publications that support the biological activity of the product.
Severini et al (2008) TLQP-21, a neuroendocrine VGF-derived peptide, prevents cerebellar granule cell death induced by serum and potassium deprivation. J.Neurochem. 104 534 PMID: 18173805
Bartolomucci et al (2006) TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc.Natl.Acad.Sci. USA 103 14584
Jethwa et al (2007) VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters. Endocrinol. 148 4044
If you know of a relevant reference for TLQP 21, please let us know.
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Keywords: TLQP 21, TLQP 21 supplier, VGF-derived, peptide, Neurotrophin, Receptors, TLQP21, Other, Apoptosis, Trk, 3051, Tocris Bioscience
1 Citation for TLQP 21
Citations are publications that use Tocris products. Selected citations for TLQP 21 include:
Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Front Pharmacol 288 27434 PMID: 23940034
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