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Submit ReviewToyocamycin
Description: Adenosine analog; antifungal antibiotic
Chemical Name: 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Purity: ≥98% (HPLC)
Biological Activity for Toyocamycin
Toyocamycin is an adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.
Compound Libraries for Toyocamycin
Toyocamycin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Toyocamycin
| M. Wt | 291.26 |
| Formula | C12H13N5O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 606-58-6 |
| PubChem ID | 12444444 |
| InChI Key | XOKJUSAYZUAMGJ-NNXMZFEESA-N |
| Smiles | NC1=C2C(N([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)C=C2C#N)=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Toyocamycin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.13 | 100 |
Preparing Stock Solutions for Toyocamycin
The following data is based on the product molecular weight 291.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.43 mL | 17.17 mL | 34.33 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.87 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.43 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Product Datasheets for Toyocamycin
References for Toyocamycin
References are publications that support the biological activity of the product.
Ri et al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79 PMID: 22852048
Nishioka et al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586 PMID: 2177464
Yen et al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797 PMID: 16556935
If you know of a relevant reference for Toyocamycin, please let us know.
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Keywords: Toyocamycin, Toyocamycin supplier, Toyocamycin, antibiotics, adenosine, analog, antifungal, anticancer, PI3K, phosphoinositide, 3-kinases, phosphatidylinositol, inhibitors, inhibits, Antibiotics, Antifungals, 5270, Tocris Bioscience
1 Citation for Toyocamycin
Citations are publications that use Tocris products. Selected citations for Toyocamycin include:
Tanabe et al (2018) IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. Oncotarget 9 14428 PMID: 29581854
Do you know of a great paper that uses Toyocamycin from Tocris? Please let us know.
Reviews for Toyocamycin
Average Rating: 5 (Based on 1 Review.)
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The pathway of inhibition of auxin-responsive gene expression by Toyocamycin was studied.
By
Josh McKay on 02/18/2019
Species: Human
The pathway of inhibition of auxin-responsive gene expression by Toyocamycin was studied. Solutions prepared in DMSO can be diluted 20-fold in water.
