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Submit ReviewTravaprost
Description: Potent and selective FP prostaglandin receptor agonist
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methyethyl ester
Purity: ≥98% (HPLC)
Biological Activity for Travaprost
Travaprost is a FP prostaglandin receptor agonist. Exhibits submicromolar affinity for DP, EP, IP and TP receptors. Stimulates intracellular Ca2+ mobilization. Ocular hypotensive agent.
Technical Data for Travaprost
| M. Wt | 500.55 |
| Formula | C26H35F3O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 157283-68-6 |
| PubChem ID | 5282226 |
| InChI Key | MKPLKVHSHYCHOC-AHTXBMBWSA-N |
| Smiles | O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@H](O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Travaprost
References for Travaprost
References are publications that support the biological activity of the product.
Hellberg et al (2001) Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J.Ocul.Pharmacol.Ther. 17 421 PMID: 11765147
Sharif et al (1999) [3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travo. (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor. J.Pharm.Pharmacol. 51 685 PMID: 10454045
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Keywords: Travaprost, Travaprost supplier, Supplier, Travoprost, FP, receptor, agonist, prostaglandin, F2a, F2alpha, ocular, hypotensive, Prostanoid, Receptors, 4218, Tocris Bioscience
Citations for Travaprost
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