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Submit ReviewTris DBA
Description: N-myristoyltransferase-1 inhibitor; antiproliferative
Chemical Name: Tris(dibenzylideneacetone) dipalladium
Biological Activity for Tris DBA
Tris DBA is a N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst.
Technical Data for Tris DBA
| M. Wt | 915.73 |
| Formula | C51H42O3Pd2 |
| Storage | Store at RT |
| CAS Number | 51364-51-3 |
| PubChem ID | 9811564 |
| InChI Key | CYPYTURSJDMMMP-WVCUSYJESA-N |
| Smiles | [Pd].[Pd].O=C(\C=C\C1=CC=CC=C1)/C=C/C1=CC=CC=C1.O=C(\C=C\C1=CC=CC=C1)/C=C/C1=CC=CC=C1.O=C(\C=C\C1=CC=CC=C1)/C=C/C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tris DBA
References for Tris DBA
References are publications that support the biological activity of the product.
Bhandarkar et al (2008) Tris(Dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clin.Cancer Res. 14 5743 PMID: 18794083
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Keywords: Tris DBA, Tris DBA supplier, N-myristoyltransferase-1, inhibitors, inhibits, antiproliferative, Transferases, TrisDBA, Other, Post-translational, Modifications, 3416, Tocris Bioscience
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