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Submit ReviewTyrphostin B44, (+) enantiomer
Description: EGFR-kinase inhibitor
Chemical Name: (S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Biological Activity for Tyrphostin B44, (+) enantiomer
Tyrphostin B44, (+) enantiomer is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Slightly less active than the (-) enantiomer.
(-)-enantiomer also available.
Technical Data for Tyrphostin B44, (+) enantiomer
| M. Wt | 308.34 |
| Formula | C18H16N2O3 |
| Storage | Desiccate at +4°C |
| CAS Number | 133550-37-5 |
| PubChem ID | 5328769 |
| InChI Key | UMGQVUWXNOJOSJ-DGGAMASNSA-N |
| Smiles | OC1=C(O)C=CC(\C=C(C(N[C@@H](C)C2=CC=CC=C2)=O)/C#N)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tyrphostin B44, (+) enantiomer
References for Tyrphostin B44, (+) enantiomer
References are publications that support the biological activity of the product.
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
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Keywords: Tyrphostin B44, (+) enantiomer, Tyrphostin B44, (+) enantiomer supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factor, Receptors, ErbB, Her, RTK, Receptor, Tyrosine, Kinases, RTKs, (+)-TyrphostinB44, 0579, Tocris Bioscience
Citations for Tyrphostin B44, (+) enantiomer
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