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Submit ReviewUCLA GP130 2
Description: gp130 agonist; brain penetrant and neuroprotectant
Chemical Name: N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98% (HPLC)
Biological Activity for UCLA GP130 2
UCLA GP130 2 is a gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant.
Compound Libraries for UCLA GP130 2
UCLA GP130 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for UCLA GP130 2
| M. Wt | 270.32 |
| Formula | C15H11FN2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 339303-87-6 |
| PubChem ID | 1284592 |
| InChI Key | HXVFUSRCVKYALB-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UCLA GP130 2
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.03 | 100 | |
| ethanol | 27.03 | 100 |
Preparing Stock Solutions for UCLA GP130 2
The following data is based on the product molecular weight 270.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.7 mL | 18.5 mL | 36.99 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.7 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for UCLA GP130 2
References for UCLA GP130 2
References are publications that support the biological activity of the product.
Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID: 29161500
If you know of a relevant reference for UCLA GP130 2, please let us know.
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Citations for UCLA GP130 2
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