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UNC 2881

Cat. No. 6537 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent Mer kinase inhibitor
Chemical Name: 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for UNC 2881

UNC 2881 is a potent Mer kinase inhibitor. Displays >55-fold selectivity for Mer kinase over other TAM receptor tyrosine kinase family members (IC50 values are 4.3 nM, 0.25 μM and 0.36 μM for Mer, Tyro3 and Alk, respectively). Inhibits Mer phosphorylation in vitro. Also inhibits platelet aggregation in response to Type I collagen.

Compound Libraries for UNC 2881

UNC 2881 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UNC 2881

M. Wt 463.58
Formula C25H33N7O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1493764-08-1
PubChem ID 71721525
InChI Key NPVXOWLPOFYACO-UHFFFAOYSA-N
Smiles CCCCNC1=NC=C(C(N[C@H]2CC[C@@H](CC2)O)=N1)C(NCC3=CC=C(N4C=CN=C4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UNC 2881

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.18 50

Preparing Stock Solutions for UNC 2881

The following data is based on the product molecular weight 463.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.31 mL 21.57 mL 43.14 mL
2.5 mM 0.86 mL 4.31 mL 8.63 mL
5 mM 0.43 mL 2.16 mL 4.31 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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References for UNC 2881

References are publications that support the biological activity of the product.

Zhang et al (2013) Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem. 56 9693 PMID: 24219778

If you know of a relevant reference for UNC 2881, please let us know.

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Keywords: UNC 2881, UNC 2881 supplier, UNC2881, Mer, kinase, inhibitors, inhibts, TAM, receptor, tyrosine, kinases, platelet, aggregation, Other, RTKs, 6537, Tocris Bioscience

Citations for UNC 2881

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