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UNC 8732

Cat. No. 8118 Submit a Review Datasheet / COA / SDS
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Description: Potent NSD2 Degrader
Chemical Name: N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for UNC 8732

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC50 = 60 nM; Dmax = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC8732 page on the SGC website.

Technical Data for UNC 8732

M. Wt 723.75
Formula C35H39N5O5.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2929304-06-1
InChI Key HFQMCVDNCFEJSF-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C6C(CCN(C6)C(CCCCCN)=O)=C5.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UNC 8732

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 72.37 100
ethanol 72.37 100

Preparing Stock Solutions for UNC 8732

The following data is based on the product molecular weight 723.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.38 mL 6.91 mL 13.82 mL
5 mM 0.28 mL 1.38 mL 2.76 mL
10 mM 0.14 mL 0.69 mL 1.38 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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References for UNC 8732

References are publications that support the biological activity of the product.

If you know of a relevant reference for UNC 8732, please let us know.

View Related Products by Target

Keywords: UNC 8732, UNC 8732 supplier, UNC8732, E3, ligase, degrader, degrades, degraders, NSD2, nuclear, receptor, binding, SET, domain-containing, 2, potent, selective, Other, Degraders, 8118, Tocris Bioscience

Citations for UNC 8732

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Currently there are no citations for UNC 8732. Do you know of a great paper that uses UNC 8732 from Tocris? Please let us know.

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia