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Submit ReviewUPF 1069
Description: PARP-2 inhibitor
Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
Purity: ≥99% (HPLC)
Biological Activity for UPF 1069
Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
Technical Data for UPF 1069
| M. Wt | 279.29 |
| Formula | C17H13NO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1048371-03-4 |
| PubChem ID | 25015515 |
| InChI Key | JJWMRRNGWSITSQ-UHFFFAOYSA-N |
| Smiles | O=C2NC=CC1=C(OCC(C3=CC=CC=C3)=O)C=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UPF 1069
References for UPF 1069
References are publications that support the biological activity of the product.
Moroni et al (2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br.J.Pharmacol. 157 854 PMID: 19422384
Pellicciari et al (2008) On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem 3 914
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Keywords: UPF 1069, UPF 1069 supplier, PARP2, poly(ADP-ribose), polymerases, inhibitors, inhibits, UPF1069, Poly(ADP-ribose), Polymerase, 3736, Tocris Bioscience
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Currently there are no citations for UPF 1069.
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Cell Cycle and DNA Damage Research Product Guide
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