Home / Pharmacology / Ion Channels / Ionophores / Valinomycin

Valinomycin

Cat. No. 3373 3 Citations 2 Reviews Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective K+ ionophore
Chemical Name: Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Purity: ≥90% (HPLC)
Datasheet
Citations (3)
Reviews (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Valinomycin

Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data for Valinomycin

M. Wt 1111.32
Formula C54H90N6O18
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 2001-95-8
PubChem ID 3000706
InChI Key FCFNRCROJUBPLU-DNDCDFAISA-N
Smiles O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Valinomycin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.78 25
ethanol 27.78 25

Preparing Stock Solutions for Valinomycin

The following data is based on the product molecular weight 1111.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 3.6 mL 18 mL 35.99 mL
1.25 mM 0.72 mL 3.6 mL 7.2 mL
2.5 mM 0.36 mL 1.8 mL 3.6 mL
12.5 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Valinomycin

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Valinomycin

References are publications that support the biological activity of the product.

Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325 PMID: 3158656

Abdalah et al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 405 68

Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70 387

If you know of a relevant reference for Valinomycin, please let us know.

View Related Products by Target

Keywords: Valinomycin, Valinomycin supplier, Selective, K+, ionophores, Potassium, antibiotics, Ionophores, Antibiotics, 3373, Tocris Bioscience

3 Citations for Valinomycin

Citations are publications that use Tocris products. Selected citations for Valinomycin include:

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. J Cancer 11 e0154932 PMID: 27183222

Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023

MacDonald et al (2019) A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics. Commun Biol 2 258 PMID: 31312727

Do you know of a great paper that uses Valinomycin from Tocris? Please let us know.

Reviews for Valinomycin

Average Rating: 4.5 (Based on 2 Reviews.)

5 Star
50%
4 Star
50%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Valinomycin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By Anonymous on 02/01/2020
Assay Type: In Vitro
Species: Other

Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience

PMID: 27183222
review image
Valimomycin was used in oxidative phosphorylation studies.
By Jade Smith on 02/05/2019
Species: Human

Valimomycin was used in oxidative phosphorylation studies. Performed well and gives repeatable results.

review image