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Submit ReviewVinpocetine
Discontinued Product
0757 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Na+ channel blocker
Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity for Vinpocetine
Vinpocetine is a phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.
Technical Data for Vinpocetine
| M. Wt | 350.46 |
| Formula | C22H26N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 42971-09-5 |
| PubChem ID | 443955 |
| InChI Key | DDNCQMVWWZOMLN-IRLDBZIGSA-N |
| Smiles | O=C(OCC)C5=C[C@@]2(CC)[C@@]1([H])C4=C(C3=CC=CC=C3N45)CCN1CCC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Vinpocetine
References for Vinpocetine
References are publications that support the biological activity of the product.
Hagiwara et al (1984) Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem.Pharmacol. 33 453 PMID: 6322804
Molnar and Erdo (1995) Vinpocetine is as potent as phen. to block voltage-gated Na+ channels in rat cortical neurons. Eur.J.Pharmacol. 273 303 PMID: 7737339
Merck Index 12 10128
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Keywords: Vinpocetine, Vinpocetine supplier, PDE1, inhibitors, inhibits, Na+, channel, blockers, Phosphodiesterases, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 0757, Tocris Bioscience
2 Citations for Vinpocetine
Citations are publications that use Tocris products. Selected citations for Vinpocetine include:
Lee et al (2015) Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. EMBO Mol Med 194 5990 PMID: 25972475
Robichaud et al (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135 113 PMID: 11786486
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