Home / Pharmacology / Ion Channels / Potassium Channels / Non-selective / Other Potassium Channels / Non-selective / Other Potassium Channel Inhibitors / VU 0546110

VU 0546110

Cat. No. 7956 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective SLO3 potassium channel inhibitor
Chemical Name: 1-[4-[[(4-Methoxyphenyl)thio]methyl]-1-piperidinyl]-2-[4-[(1-methylethyl)sulfonyl]phenyl]ethanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for VU 0546110

VU 0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50 = 64 μM). It shows 40-fold selectivity over SLO1. It completely blocks heterologous SLO3 currents and endogenous K+ currents. VU 0546110 inhibits sperm hyperpolarisation and prevents its hyperactivated mobility.

Technical Data for VU 0546110

M. Wt 461.64
Formula C24H31NO4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1421523-00-3
PubChem ID 71800954
InChI Key IUFAHCWQEABYHO-UHFFFAOYSA-N
Smiles O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0546110

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.16 100
ethanol 23.08 50

Preparing Stock Solutions for VU 0546110

The following data is based on the product molecular weight 461.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.66 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for VU 0546110

References are publications that support the biological activity of the product.

Lyon et al (2023) A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proc.Natl.Acad.Sci.U.S.A. 120 e2212338120 PMID: 36649421

If you know of a relevant reference for VU 0546110, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective / Other Potassium Channel Inhibitors

Keywords: VU 0546110, VU 0546110 supplier, VU0546110, selective, potassium, channels, K+, currents, slo, channel, hyperpolarisation, Non-selective, /, Other, Potassium, Channels, 7956, Tocris Bioscience

Citations for VU 0546110

Citations are publications that use Tocris products.

Currently there are no citations for VU 0546110. Do you know of a great paper that uses VU 0546110 from Tocris? Please let us know.

Reviews for VU 0546110

There are currently no reviews for this product. Be the first to review VU 0546110 and earn rewards!

Have you used VU 0546110?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review